Total 2 Senior Executive level Science / R&D / Research job vacancies in Cambridgeshire, CB4 1PX

Your new company
You will be joining a world leading research institute based in the Cambridge area - who have a wide range of partnerships within academia and pharmaceutical & biotech companies - focusing on research within cancer.
The institution has invested heavily in equipment and lab upgrades and fosters a highly collaborative and friendly work environment, where you will be working with leading experts within cancer and biological research.They also offer very generous benefits, a flexible approach to working and make significant investment into the training and development of their staff, so there will be a number of opportunities to develop new and advance existing skills.


Your new role
You will be joining a prestigious research group working with some of the leading scientists in the genetics field carrying out research work to identify new approaches to tackle cancer.
Main responsibilities will include:

• Lead innovative research in molecular biology to uncover fundamental mechanisms related to genetic and protein functions in cancer.
• Investigate interactions between modified bases and proteins, focusing on their impact on genome functions like transcription and chromatin organisation.
• Develop new techniques to study the dynamics of modified bases and their binding proteins, utilising chemical and genetic approaches.
• Analyse genetic/genomic and other omics data sets to provide insights and use these to design future experiments.
• Explore genetic targets for synthetic lethality opportunities in cancer.
• Manage your own research projects while collaborating with others, ensuring meticulous record-keeping and resource management.
• Share your findings through presentations and publications, and help to mentor PhD students.

What you'll need to succeed
As well as strong communication and organisational skills, you should have:

• A PhD (or be nearing completion) in molecular biology, biochemistry, cancer genomics, or related fields, or significant equivalent experience
• Proficiency in molecular biology techniques, including RNA/DNA analysis, PCR, protein analysis, and western blotting.
• Advanced cloning skills, with experience in genetic engineering, vector construction, and CRISPR/Cas9 systems.
• Expertise in recombinant protein design and expression, utilising systems like E. coli, along with purification methods such as FPLC and mass spectrometry.
• Familiarity with genomic technologies like ChIP-seq, RNA-seq, and single-cell methods, preferably within oncology research, though this is not essential.

It would be an advantage to have good data analysis skills and experience using programming / scripting languages such as Python and/or R, along with tools like MATLAB and Bioconductor, however training can be provided.

What you'll get in return
An exciting opportunity to work with one of the leading research institutes in the country, excellent career and skills development, a great working atmosphere and the chance to make a real impact on cancer research.


What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call me on 0203 465 0057.
If this job isn't quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career.

Keywords: biology, biologist, molecular, cell, gene, expression, editing, CRISPR, Cas9, recombinant, protein, NGS, genetic, genomic, cancer, cloning, vector, RNAseq, ChIPseq, research, science, pharmaceutical, biotech, drug, discovery, development, R&D, R, python

Job Title: Senior Research Associate - Synergy

Location: Cambridge, UK

Salary: £35,000 p/a

contract: 12 month FTC

A highly motivated Senior Research Associate (SRA) in protein biochemistry and molecular assays. The SRA will be responsible for the production of condensate-forming proteins and carry out compound screening using our proprietary microfluidic platform, activities that are critically important to the success of our drug-discovery program.

This role will require a good knowledge of problem-solving capability to successfully express and purify challenging protein systems from heterologous hosts. The candidate should demonstrate expertise and technical proficiency in molecular biology and protein chromatography methods. Comprehensive training will be provided for the operation of our specialized screening technologies.

Synergy, part of SRG, offer a range of scientific solutions to different Clients in the Life Sciences sector. We can offer a competitive salary, a range of excellent benefits and access to training & development opportunities within the role.

Responsibilities:

· Express and purify recombinant proteins, including cloning and construct generation.

· Problem solve and innovate to produce proteins in large scales from heterologous expression systems including insect and bacterial cells.

· Analyse data, troubleshoot technical difficulties, implement solutions, and present results regularly at team meetings.

· Maintain and implement laboratory practices to a high standard, including accurate record keeping using electronic laboratory notebook systems.

· Work effectively and collaboratively with cross-disciplinary teams to contribute to the vision, strategy, and tactics of the organization.

Requirements:

· BSc/MSc in Biochemistry, Biophysics, or a related field, or sufficient industry experience.

· Solid industry experience, working in protein biochemistry, molecular biology, or related disciplines (2-3 years).

· A demonstrated ability to design and execute recombinant protein expression and purification strategies using mammalian, insect, yeast, ba

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.