Total 1,086 job vacancies by A*star Research Entities

The Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STR) is seeking applications for an outstanding scientist in the field of quantum computing.

The Bioinformatics Institute (BII) is a computational biology research and postgraduate training institute as well as a national resource centre in bioinformatics within the Biomedical Research Council (BMRC) of A*STAR. Our scientists aim to understand the biomolecular mechanisms that underlie biomedical phenomena by developing sophisticated computational methods to support discovery from a secure and sustainable data hub to cross-disciplinary AI/ML analysis and data integration. We analyse a wide spectrum of biological and clinical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images from local and international academic, hospital and industry collaborators, public resources and also from in-house efforts. The institute has a vibrant and diverse research portfolio that includes infectious diseases, computational toxicology, precision medicine, oncology and drug discovery.

Job scope and responsibilities:

· Lead efforts in using quantum computing to analyze biomolecular and biomedical data (e.g. protein-ligand interactions, molecular docking, protein/RNA folding, molecular dynamics simulations, imaging, spatial ohmics) and couple it with methods such as quantum machine learning, quantum monte carlo etc, contributing to the development of a broader initiative encompassing AI in drug discovery.

· Collaborate closely with scientists within the Bioinformatics Institute, within A*STAR and within the local ecosystem.

· Lead or participate in research grant proposals.

Requirements:

· Minimum PhD in a related field.

· 5 years or more of postdoctoral experience in quantum computing, demonstrating outstanding research outcomes and strong publication records.

· The candidate must have experience in quantum computing software development/applications, especially with NISQ machines.

· Excellent communication (oral and written) and public speaking skills.

· Strong records of strategic thinking ability.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description and Requirements

A postdoctoral senior/ research fellow (scientist) position is available in Tan Yee Joo’s lab to work on hepatitis B virus. Candidate is required to work closely with fellow lab members and collaborators in a joint grant.

Requirements:

• PhD in Biomedical Science or related fields
• Highly experienced in common biochemical techniques including PCR, real-time PCR, Western blot and immunofluorescence assays
• Highly experienced in mammalian cell culture methodologies including gene knockout/knockdown, transient and stable transfections
• Experienced in virology is preferred
• Experienced in performing pathway analysis of datasets from proteomics and transcriptomics experiments is preferred
• Experienced in chromatin immunoprecipitation assay is preferred
• Have a strong publication record in peer-reviewed journals
• Be able to work in a team and conduct independent research with excellent analytical, technical and problem-solving skills

Job Description and Requirements

A postdoctoral senior/ research fellow (scientist) position is available in Tan Yee Joo’s lab to work on hepatitis B virus. Candidate is required to work closely with fellow lab members and collaborators in a joint grant.

Requirements:

• PhD in Biomedical Science or related fields
• Highly experienced in common biochemical techniques including PCR, real-time PCR, Western blot and immunofluorescence assays
• Highly experienced in mammalian cell culture methodologies including gene knockout/knockdown, transient and stable transfections
• Experienced in virology is preferred
• Experienced in performing pathway analysis of datasets from proteomics and transcriptomics experiments is preferred
• Experienced in chromatin immunoprecipitation assay is preferred
• Have a strong publication record in peer-reviewed journals
• Be able to work in a team and conduct independent research with excellent analytical, technical and problem-solving skills

The “Cellular Basis of Neural Diseases” laboratory in the Institute of Molecular and Cell Biology, A*STAR invites applications for a position as Senior Scientist I (Postdoctoral Research Fellow) in Cellular and Metabolic Therapies for Neurological Diseases.

The goal of the program is to derive clinically relevant neural cell types from induced pluripotent stem cells for development of novel therapies. This will be achieved through enhanced biological understanding of the disease progression and identification of new disease targets.

Interested candidates should have a PhD degree in Biomedical Sciences, Neuroscience, Stem Cells and Regenerative Biology or a relevant field. The ideal candidate should possess the following characteristics:

· Passionate and committed to advance the frontiers of Stem Cell/Neuroscience research

· Excellent communication skills (both written and oral)

· A team player who can perform well with colleagues as well as independently

· Proven track record of scientific research evidenced by strong publication record

· Experience with neural organoid cultures, as well as single cell RNA-seq analyses would be highly desirable

· Meticulous and organized

The Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STR) is seeking applications for an outstanding scientist in the field of quantum computing.

The Bioinformatics Institute (BII) is a computational biology research and postgraduate training institute as well as a national resource centre in bioinformatics within the Biomedical Research Council (BMRC) of A*STAR. Our scientists aim to understand the biomolecular mechanisms that underlie biomedical phenomena by developing sophisticated computational methods to support discovery from a secure and sustainable data hub to cross-disciplinary AI/ML analysis and data integration. We analyse a wide spectrum of biological and clinical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images from local and international academic, hospital and industry collaborators, public resources and also from in-house efforts. The institute has a vibrant and diverse research portfolio that includes infectious diseases, computational toxicology, precision medicine, oncology and drug discovery.

Job scope and responsibilities:

· Lead efforts in using quantum computing to analyze biomolecular and biomedical data (e.g. protein-ligand interactions, molecular docking, protein/RNA folding, molecular dynamics simulations, imaging, spatial ohmics) and couple it with methods such as quantum machine learning, quantum monte carlo etc, contributing to the development of a broader initiative encompassing AI in drug discovery.

· Collaborate closely with scientists within the Bioinformatics Institute, within A*STAR and within the local ecosystem.

· Lead or participate in research grant proposals.

Requirements:

· Minimum PhD in a related field.

· 2 years or more of postdoctoral experience in quantum computing, demonstrating outstanding research outcomes and strong publication records.

· The candidate must have experience in quantum computing software development/applications, especially with NISQ machines.

· Excellent communication (oral and written) and public speaking skills.

· Strong records of strategic thinking ability.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

• Responsibilities: mouse colony management, genotyping, mouse surgery, immunostaining, tissue sectioning and staining, and other technical support requested by lab members
• Provide technical support for research

JOB REQUIREMENT

• Bachelor in Biological Science and Life Science disciplines or equivalent
• Experience with animal work will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work and able to work flexible hours
• Ability to multitask, work independently and also as part of a team
  Excellent communication (verbal and written) and presentation skills

The A*STAR Skin Research Labs (A*SRL) and Skin Research Institute of Singapore (SRIS) aim to develop novel and efficient products and therapies to prevent age-related loss of skin function, treat skin conditions, and reduce the clinical burden of skin diseases. To facilitate the identification of new hits or tool compounds, the Asian Skin Biobank at SRIS has acquired different compound libraries (natural compounds, FDA-approved drugs, kinase inhibitors) and is looking for a motivated and skilled Scientist/Senior Scientist to set and lead the library screening platform. This position is ideal for an individual with a strong background in cell biology and biochemistry, experience in high throughput drug screening, and solid expertise in skin biology, skin models and cell-based assays for the validation of potential targets.

Key Responsibilities:

• Conceptualize cell- based assays for drug screening and hit identification.
• Design and optimize biochemical cell- based assays with various readouts.
• Develop reporter lines to quantify expression of gene of interests.
• Plan, execute and analyse high throughput screening of library compounds for inter- and intra-institutional collaborations.
• Design and execute in vitro functional assays for hit/target validation.
• Serve as primary point of liaison and coordination between investigators, researchers, sponsoring organizations, and Tech Biz.
• Present findings at internal and external meetings and conferences.
• Write research reports and actively contribute to the preparation of publications.

Requirements:

• PhD degree in Biology, Chemistry, Pharmacy, or a related field.
• At least 5 years of relevant experience in screening of compound libraries, development of specialised cell lines, and cell-based assays.
• Knowledge in skin cell biology and diseases.
• Strong organisational and problem-solving skills.
• Excellent oral and written communication and presentation skills.
• Able to work independently, and as part of a team, with a positive and enthusiastic attitude.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.

Job Description:

The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the suppression by the tumor microenvironment.

Job Requirements:

• PhD in Immunology
• Possess at least a minimum of 2 years relevant work experience
• Substantial background and publication records in cancer immunology particularly on T and NK cells
• Experience working with patient-derived samples and experimental models
• Good organisational, verbal and interpersonal skills
• Exhibit ability in mentoring and lead the project

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with at least 5 years experience in dermatology, immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Digital Health Accelerator (DHA) is led by A*STAR, Ministry of Health (MOH) Singapore, SingHealth, National Healthcare Group (NHG), and National University Health System (NUHS). DHA supports innovators in driving adoption and scaling of market ready or near-market ready digital health solutions. DHA is hosted by Singapore's Diagnostics Development Hub (DxD Hub).

The DHA integration engineer is responsible for planning and developing workflow and technical interfaces between healthcare IT systems. She/He will work with DHA Project Managers, Solution Architects, health systems and companies to accomplish this objective. She/He may also be called upon to advise other developers on integration standards.

Responsibilities:

• You’ll be involved in the development, design, build, testing, and go live phases of multiple integration projects.
• This includes scripting to conform / transform to another systems specifications.
• You will also work with internal teams to continuously improve processes and procedures around deployment of interoperability products that communicate in HIT standards-based formats such as HL7, IHE Profiles, Direct, or SMART on FHIR.
• The Integration Engineer oversees the development of new interfaces and maintain the sandbox environment up to date for application testing.

Requirements:

• Bachelor’s degree in information systems, Computer Science, Engineering, Computer Information Systems, Management Information Systems, or equivalent experience
• 3+ years’ experience in HCIT integration using established and contemporary interoperability standards (e.g. HL7, SMRT, FHIR)
• Experience with SQL and relational databases, and communication using secure protocols.
• Ability to work in a team environment alongside developers and deployment teams.
• Utilise engines like Mirth Connect or Rhapsody to have a standard way of integration using both HL7 and DICOM
• Knowledge in developing and configuring Context Launch requirements according to AES 256 standards.
• Assess and customise integrations (HL7 / FHIR / DICOM) based on the project to specific workflow.
• Experience with cloud deployments and/or pipelines, especially Pivotal Cloud Foundry
• Experience with popular healthcare integration engines with ability to recommend and/or select different integration approaches depending on the desired outcomes for the system.
• Strong communication skills and ability to work with project stakeholders from different backgrounds (e.g. technical, clinical)
• Experience integrating with Singapore public hospital technical stack and working with Synapxe are a plus.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description:

DxD Hub is seeking an experienced UI/UX engineer for our product development for our Digital Diagnostics Team. In this role, you will play a crucial role in driving the user interface and experience of digital health products in collaboration with external partners (especially clinicians). The ideal candidate should possess a strong usability engineering skills and able to translate expectation to visualisation and handover to technical team.

Job Responsibilities:

• Design innovative app experiences based on the understanding of personas, their behaviors and needs as well as competitive market insights.
• Collaborate with partners to understand their goals and propose a user-centric approach to improve digital services.
• Communicate design ideas through tools such as sketches, user journeys, storyboards, mind maps, wireframes, and clickable prototypes.
• Drive user research activities such as, usability testing, user interviews, surveys, and translate research findings into meaningful recommendations.
• Guide all aspects of UX including design research, design strategy, user experience, usability testing, interaction/content design and prototyping.
• Work closely with Product Owners to ensure all design work meets user needs and business requirements.
• Create a design-minded environment and build design capabilities amongst project team members.

Job Requirements:

• Degree or Diploma in Human Computer Interactions, Design, Psychology, Computer Science or related fields
• 1-2 years’ experience in user-centered design with hands on experience building visual identities for web and mobile app UI.
• Experience in delivering wireframes, UX flows, mockups, interactive prototypes, design specifications, and final assets.
• Experience with design/wireframing software such as: Figma, Sketch, Adobe suite, or equivalent.
• Strong portfolio showcasing your best design work for web and mobile.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. The ideal candidate need not specialise in all three aspects, but should be technically strong in at least one of these areas.

JOB REQUIREMENT

• Ph.D. in Immunology or Cell Biology or Biochemistry or Mass Spectrometry.
• Expertise in T-cell engineering highly preferred.
• Interested in data and computation.
• Solid publication record and strong scientific writing skills.
• Strong motivation and energy to lead project.
• Good organisational, verbal and interpersonal skills.
• Need to be a team player.
• Keen to learn

We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.

Job Description:

The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the suppression by the tumor microenvironment.

Job Requirement:

• PhD in Immunology or Cell Biology
• Possess at least a minimum of 5 years relevant work experience
• Substantial background and publication records in cancer immunology, particularly on T and NK cells
• Experience working with patient-derived samples and experimental models
• Good organisational, verbal and interpersonal skills
• Exhibit ability in mentoring and leading the project

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description

The Research Fellow in Computational Immunology/Bioinformatics will play a key role in advancing our research projects by conducting expert analyses of next-generation sequencing (NGS) data. This includes single-cell RNA sequencing, T-/B-cell receptor analysis, long-read sequencing, and spatial omics analysis using imaging data. The fellow will have the opportunity to work alongside a multidisciplinary team of leading immunologists, oncologists, and AI scientists, contributing to pioneering research that utilizes diverse data types, ranging from cell lines to clinical samples. The position will leverage the fellow’s bioinformatics expertise to innovate and contribute to the development of effective T-cell epitopes for cancer vaccine design.

Job Responsibilities

• Perform advanced single-cell analyses to identify distinct cell phenotypes and interactions, elucidating the transcriptomic landscape that drives tumor progression and/or responses to treatments.
• Develop robust bioinformatics pipelines for analysing TCR and in-situ tumor-immune spatial organization using long-read sequencing and high-plex immunofluorescence data, respectively.
• Work collaboratively with an interdisciplinary team of biologists, clinicians, and AI scientists to contextualize findings within complex disease landscapes.
• Manage data curation and ensure the integrity and accessibility of datasets.
• Maintain up-to-date knowledge of bioinformatics methodologies and stay informed about new technologies and computational tools.
• Communicate findings through scientific publications, presentations, and reports for both academic and non-academic audiences.

Job Requirement

• PhD in Immunology, Bioinformatics, Computational Biology, Systems Biology, or a related field.
• Minimum of 5 years of relevant experience in omics data analysis.
• Proficient in programming languages such as R and Python, with extensive use of bioinformatics tools and public databases.
• Demonstrated expertise in statistical data analysis and the application of machine learning.
• Skilled in using data visualization tools and software.
• Knowledge of cancer immunology and molecular biology principles.
• Proven publication record in peer-reviewed journals within the bioinformatics field or related areas.
• Exceptional problem-solving skills, capable of working independently and collaboratively.
• Excellent verbal and written communication skills.
• Advanced programming skills in R and Python.
• Experience with server-based and high-performance computing environments.
• Experience in computational tool development.
• Expertise in managing and analyzing large datasets from various omics platforms.
• Experience in computer vision or image processing.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A Research Officer position is available in Dr. Anand Andiappan Lab at the Singapore Immunology Network (SIgN). The RO position is to support the research work of the team that focuses on studying the role of immune system in eczema and allergies. The candidate will work on primary cells from cohorts and cell culture systems towards understanding immune pathophysiology of disease. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by confocal microscopy, and associated data analysis with statistical tested.

Job Duties:

• Managing safety in the lab
• Creating SOPs and lab risk assessments
• Maintaining lab inventories
• Perform other lab administrative duties and operations such as ordering and tracking lab budget
• Experience with human and mouse blood/tissue sample handling and processing (e.g. isolation of specific immune cell population) and knowledge of immune cell biology is encouraged
• Experience with flow cytometry analysis for different immune cell population and functional immune assays will be an advantage

Job Requirements:

• Degree in Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in molecular biology techniques, immunology, cancer cell biology, cell culture and flow cytometry
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills
• Candidates are expected to be highly motivated to work in research and able to perform tasks independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.